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WENSEL, THEODORE

One or more keywords matched the following properties of WENSEL, THEODORE

Property	Value
overview	Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2012, it ranked 11th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research. The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include: Visual transduction in the vertebrate retina G protein pathways and proteins that regulate them in the retina and the brain RGS proteins: GAPs for heterotrimeric G proteins Biomembranes Ocular Proteomics Gene repair in neurons Time-resolved fluorescence and luminescence Electron and x-ray crystallography Cryo-electron tomography Gene engineering in mice and frogs TRP Channels
overview	Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2013, it ranked 10th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research. The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include: Visual transduction in the vertebrate retina G protein pathways and proteins that regulate them in the retina and the brain RGS proteins: GAPs for heterotrimeric G proteins Biomembranes Ocular Proteomics Gene repair in neurons Time-resolved fluorescence and luminescence Electron and x-ray crystallography Cryo-electron tomography Gene engineering in mice and frogs TRP Channels

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overview

Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2012, it ranked 11th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research. The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include: Visual transduction in the vertebrate retina G protein pathways and proteins that regulate them in the retina and the brain RGS proteins: GAPs for heterotrimeric G proteins Biomembranes Ocular Proteomics Gene repair in neurons Time-resolved fluorescence and luminescence Electron and x-ray crystallography Cryo-electron tomography Gene engineering in mice and frogs TRP Channels

overview

Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2013, it ranked 10th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research. The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include: Visual transduction in the vertebrate retina G protein pathways and proteins that regulate them in the retina and the brain RGS proteins: GAPs for heterotrimeric G proteins Biomembranes Ocular Proteomics Gene repair in neurons Time-resolved fluorescence and luminescence Electron and x-ray crystallography Cryo-electron tomography Gene engineering in mice and frogs TRP Channels

One or more keywords matched the following items that are connected to WENSEL, THEODORE

Item Type	Name
Academic Article	Functional and structural studies of TRP channels heterologously expressed in budding yeast.
Academic Article	Structure of TRPV1 channel revealed by electron cryomicroscopy.
Concept	Cryoelectron Microscopy
Academic Article	Three-dimensional architecture of murine rod cilium revealed by cryo-EM.
Academic Article	Structural and molecular bases of rod photoreceptor morphogenesis and disease.
Grant	Houston Area Molecular Biophysics Program
Academic Article	Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy.

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Cryoelectron Microscopy